The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study

• Published in: Obesity surgery Vol. 27; no. 7; pp. 1901 - 1905
• Main Authors: Marchesi, Federico, Tartamella, Francesco, De Sario, Giuseppina, Forlini, Clarissa, Caleffi, Alberta, Riccò, Matteo, Di Mario, Francesco
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-07-2017; Springer Nature B.V
• Subjects: Adult; Biomarkers; Biomarkers - blood; Brief Communication; Female; Gastric Bypass; Gastric cancer; Gastric Stump - physiopathology; Gastrins - blood; Gastrointestinal surgery; Helicobacter pylori - immunology; Humans; Immunoglobulin G - blood; Longitudinal Studies; Medicine; Medicine & Public Health; Middle Aged; Morbidity; Obesity; Obesity, Morbid - blood; Obesity, Morbid - physiopathology; Obesity, Morbid - surgery; Pepsinogens - blood; Plasma; Prospective Studies; Surgery; Surgical outcomes; Weight Loss; Women; Obesity; Gastric remnant; Gastric cancer; Bariatric surgery; Gastric bypass; Gastric biomarkers
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-017-2724-4

Background
Morpho-functional modifications of the gastric remnant after Roux-en-Y gastric bypass (RYGB) have not been completely defined, due to its inaccessibility for bioptic mapping. The aim of the study is to evaluate such modifications using Gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions.
Subjects and Methods
Twenty-four women undergoing RYGB were prospectively enrolled. Gastropanel® parameters (pepsinogens, Gastrin-17 and immunoglobulins against
Helicobacter pylori)
, biometrical/clinical data were collected preoperatively and at 6-months follow-up.
Results
All parameters showed significant reduction (
p
 < 0.05). Pepsinogen I reduction correlated with BMI percent decrease.
Conclusions
The exclusion of food transit is responsible for significant drop in gastric output, hardly representing a risk factor in the remnant carcinogenesis, being unexposed to alimentary carcinogenic agents.