Autoimmune hepatitis and primary biliary cholangitis overlap syndrome after mRNA COVID-19 vaccination

• Published in: Gülhane tıp dergisi Vol. 65; no. 3; pp. 141 - 144
• Main Authors: Çetinkaya, Nadir Süleyman, Cengiz, Mustafa, Gül Aydın, Emine
• Format: Journal Article
• Language: English
• Published: Ankara Gulhane Medical Journal 01-09-2023; Galenos Publishing House
• Subjects: Abdomen; autoimmune hepatitis; Bile ducts; Biopsy; Cholangitis; Conflicts of interest; covid-19 vaccine; COVID-19 vaccines; Edema; Gastroenterology; Health sciences; Hepatitis; Hepatology; Immunoglobulins; Laboratories; Liver cirrhosis; mrna vaccine; overlap syndrome; Patients; Phosphatase; primary biliary cholangitis; Severe acute respiratory syndrome coronavirus 2; Substance abuse treatment; Ankara Turkey; Turkey
• ISSN: 1302-0471; 2146-8052
• DOI: 10.4274/gulhane.galenos.2023.66376

The overlap syndrome indicates an association between autoimmune hepatitis (AIH) and sclerosis cholangitis or primary biliary cholangitis (PBC). We report a case of a 32-year-old patient who experienced overlap syndrome ten days after receiving the first dose of the mRNA Coronavirus disease-2019 (COVID-19) vaccine. Liver biopsy showed primarily AIH and “overlap syndrome” for PBC. Serum IgG was elevated, and ANA (1/100) and anti-mitochondrial antibody was positive. The patient’s treatment plan included prednisolone, ursodeoxycholic acid and azathioprine. Overlap syndrome related to the mRNA COVID-19 vaccines is a very rare entity. After the histopathological diagnosis of the patient, remission was achieved following treatment.