A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products

A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natur...

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Bibliographic Details
Published in:	Organic & biomolecular chemistry Vol. 14; no. 5; p. 1641
Main Authors:	Lloyd, Matthew G, D'Acunto, Mariantonietta, Taylor, Richard J K, Unsworth, William P
Format:	Journal Article
Language:	English
Published:	England 07-02-2016
Subjects:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemical synthesis 4-Butyrolactone - chemistry Biological Products - chemical synthesis Biological Products - chemistry Molecular Structure Stereoisomerism
Online Access:	Get more information
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Summary:	A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.
ISSN:	1477-0539
DOI:	10.1039/c5ob02579f