An interview with Kotaro Tanimoto

• Published in: Dental press journal of orthodontics Vol. 21; no. 4; pp. 24 - 33
• Main Authors: Braga, Emanuel, Habib, Fernando, Lisboa, Márcio
• Format: Journal Article Transcript
• Language: English
• Published: Brazil Dental Press International 01-07-2016; Dental Press Editora
• Subjects: Biomedical Research; Bone Regeneration; Cryopreservation; Curriculum; Dentistry; Humans; Japan; Orthodontics - education; Regenerative Medicine; Temporomandibular Joint Disorders - therapy
• ISSN: 2176-9451; 2177-6709; 2177-6709; 2176-9451
• DOI: 10.1590/2177-6709.21.4.024-033.INT

[...]we started the study for regeneration medicine using bone marrow-derived MSCs for treatment of cleft palate. [...]enamel matrix proteins have been recently suggested to exert various biological activities. [...]we focused on biological effects of amelogenins on bone marrow-derived MSCs. During the freezing process of vital tissue, ice crystals generated in the cell body fatally damage cells. [...]it is quite important to suppress ice crystal formation and its growth, so as to minimize cell damage as much as possible. [...]the recovery of lubricating and buffering function of the synovial fluid by maintaining the intra-articular environment is considered, for instance, by the use of HA supplements or other lubricating molecules by intra-articular injection.