Clinical description of dengue and chikungunya virus infections amongst acute febrile patients in a malaria endemic area of Mfou, the Centre region of Cameroon

• Published in: Diagnostic microbiology and infectious disease Vol. 109; no. 1; p. 116204
• Main Authors: Simo, Fredy Brice Nemg, Akoue, Rodrigue Ngape, Demanou, Maurice
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2024
• Subjects: Adolescent; Cameroon - epidemiology; Chikungunya; Chikungunya Fever - complications; Chikungunya Fever - diagnosis; Chikungunya Fever - epidemiology; Chikungunya virus - genetics; Co-infection; Dengue; Dengue - complications; Dengue - diagnosis; Dengue - epidemiology; Dengue Virus - genetics; Female; Fever - epidemiology; Humans; Malaria - complications; Malaria - epidemiology; Male; Mfou; Zika Virus; Zika Virus Infection - diagnosis; Cameroon; Co-infection; RDT; Dengue; DENV; Chikungunya; CENAME; Mfou; CHIKV
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/j.diagmicrobio.2024.116204

This study aims to determine the frequency and clinical manifestations of dengue and chikungunya viral infections in the district hospital of Mfou, Centre region of Cameroon where malaria is endemic. Blood samples were collected from suspected cases and tested for Plasmodium parasites and for the molecular detection of viral RNAs (dengue, zika and chikungunya viruses) using TRIOPLEX qPCR. A total of 108 patients were clinically suspected among which 25 % were male and 50 % were less than 15.5 years old. Of these 14.8 % (16/108) and 2.8 % (3/108) had acute dengue and chikungunya fevers respectively. Co-infection with malaria was reported in 56.3 % (9/16) of Dengue cases and 33.3 % (1/3) of chikungunya cases. Clinical profiling further revealed that nausea and vomiting show a significant difference in dengue infected individuals to those of non-infected individuals (P = 0.027). The presence of dengue fever and chikungunya fever and the absence of specific clinical manifestations highlight the need to strengthen surveillance of acute febrile infections for a better estimation of the burden of arboviruses.