Gold nanorods-silica Janus nanoparticles for theranostics

Gold nanorods-silica Janus nanoparticles for theranostics

A multi-functional gold nanorods-mesoporous silica Janus nanoparticles (NPs) were fabricated by a facile and mild strategy. These Janus NPs not only exhibit small shift of the local surface plasmon resonance wavelength but also have high potential for drug loading and low cytotoxicity. More importan...

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Bibliographic Details
Published in:Applied physics letters Vol. 106; no. 17
Main Authors: Wang, Ying-Shuai, Shao, Dan, Zhang, Lu, Zhang, Xu-Lin, Li, Jing, Feng, Jing, Xia, Hong, Huo, Qi-Sheng, Dong, Wen-Fei, Sun, Hong-Bo
Format: Journal Article
Language:English
Published: Melville American Institute of Physics 27-04-2015
Subjects:
Applied physics
Cancer
Drug delivery systems
Gold
Liver
Nanocomposites
Nanoparticles
Nanorods
Silicon dioxide
Toxicity
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Summary:A multi-functional gold nanorods-mesoporous silica Janus nanoparticles (NPs) were fabricated by a facile and mild strategy. These Janus NPs not only exhibit small shift of the local surface plasmon resonance wavelength but also have high potential for drug loading and low cytotoxicity. More importantly, the Janus nano-composites could efficiently deliver the imaging agents or drugs into liver cancer cells, at the same time the Janus NPs have good effect on photothermal, which indicate that the unique Janus NPs could be a promising candidate of theranostic system for combined photothermo-/chemo-cancer therapy.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4919454