In vivo behavior of a Sindbis virus mutant isolated from persistently infected Aedes aegypti cell cultures

A mutant of the Sindbis virus SV-S was found to interfere with the regular course of infection by the wild strain of the virus SV-W in A. aegypti mosquitoes and in suckling mice. In mosquitoes, this result was manifested by a reduced titer of SV-W in the presence of SV-S and by a failure of the mosq...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 266; p. 204
Main Author:	Peleg, J
Format:	Journal Article
Language:	English
Published:	United States 01-11-1975
Subjects:	Aedes - microbiology Aedes - physiology Animals Arbovirus Infections - microbiology Cells, Cultured Feeding Behavior Insect Vectors Mice Mutation Sindbis Virus - growth & development Sindbis Virus - isolation & purification Viral Interference Virulence
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Summary:	A mutant of the Sindbis virus SV-S was found to interfere with the regular course of infection by the wild strain of the virus SV-W in A. aegypti mosquitoes and in suckling mice. In mosquitoes, this result was manifested by a reduced titer of SV-W in the presence of SV-S and by a failure of the mosquitoes to transmit SV-W. In the brains of suckling mice, in the presence of SV-S, the growth of sc inoculated SV-W was suppressed, and as a result, the usually lethal course of infection by this virus was converted into a nonlethal one.
ISSN:	0077-8923
DOI:	10.1111/j.1749-6632.1975.tb35102.x