Antibacterial Activity of Anti-Aphthous Spray and Oral Drop: Two Thymus Commercial Products

• Published in: Pharmaceutical Sciences Vol. 23; no. 2; pp. 166 - 169
• Main Authors: Nahaei, Mohammadreza, Rahbarfam, Parisa, Kalajahi, Mahsa, Maleki Dizaj, Solmaz, Lotfipour, Farzaneh
• Format: Journal Article
• Language: English
• Published: Tabriz Tabriz University of Medical Sciences 01-06-2017
• Subjects: Antibacterial effect; Antimicrobial agents; Bacteria; Drug delivery systems; Drug stores; E coli; Escherichia coli; Food; Gram-negative bacteria; Gram-positive bacteria; Herbal medicine; Infectious diseases; Listeria; Microorganisms; Nanoparticles; Oils & fats; Pseudomonas aeruginosa; Salmonella; Staphylococcus aureus; Streptococcus pyogenes; Studies; Thymus
• ISSN: 1735-403X; 2383-2886; 2383-2886
• DOI: 10.15171/PS.2017.24

Herbal drugs may possess helpful pharmacology effects and the same potential as conventional drugs. [...]the growth in utilization of medicinal plants and also the development of attentiveness has improved the skill of pharmacists and chemists in order to reduce current problems such as side effects of conventional drugs.1-4 Like other medicinal plants, aromatic plants have been applied for their medicinal properties for centuries. The genus thymus contains about 350 species of herbaceous plants and is native to temperate regions in Europe, North Africa and Asia.1 Thymus species have medicinal and cosmetics applications.3 The antifungal and antibacterial activity of thymus is reported by several investigators.2-4 Oussalah et al reported antimicrobial activity of thymus vulgaris (with a MIC < 0.1% (v/v)) for some pathogenic bacteria (including Escherichia coli, Listeria monocytogenes, Salmonella paratyphi and Staphylococcus aureus).5 Maksimović et al confirmed that essential oil of thymus possesses notable in vitro antimicrobial activity against S. aureus, Enterococcus faecalis, Pseudomonas aeruginosa, E. coli.1 Marino et al assessed the antimicrobial activity of thyme essential oils against nine strains of Gram-negative bacteria and six strains of Gram-positive bacteria. Discussion The previous researches have shown that most aspects of thymus medicinal applications are related to the various levels of thymol and/or carvacrol, phenolic derivatives with strong and wide-spectrum antimicrobial activity.1,8 Based on MIC and MBC results, thymus oral drop exhibited inhibitory effects against Gram negative bacteria (P. aeruginosa and E. coli) whereas anti-aphthous spray showed inhibitory effects against both Gram positive and Gram negative bacteria (S. aureus, S. pyogenes, P. aeruginosa). [...]development of precise and repeatable manufacturing processes with reproducible pharmaceutical products is necessary that can decrease batch to batch variations.10 Also the assay method is of great importance in evaluation of antimicrobial activity.11-13 The results of disk diffusion method showed "zones of growth inhibition" only for S. aureus and S. pyogenes and no "zones of growth inhibition" for other bacteria in the case of both products.