Polymorphisms of β 1-adrenoreceptor gene and cardiovascular complications in patients with thyrotoxicosis

• Published in: BioMed research international Vol. 2014; pp. 402897 - 7
• Main Authors: Babenko, A Y, Grineva, E N, Savitskaja, D A, Kravchuk, E N, Solncev, V N, Kostareva, A A
• Format: Journal Article
• Language: English
• Published: United States 2014
• Subjects: Adult; Amino Acid Substitution - genetics; Atrial Fibrillation - etiology; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - etiology; Cardiovascular Diseases - genetics; Case-Control Studies; Female; Gene Frequency - genetics; Genetic Predisposition to Disease; Graves Disease - genetics; Humans; Male; Polymorphism, Single Nucleotide - genetics; Receptors, Adrenergic, beta-1 - genetics; Thyrotoxicosis - complications; Thyrotoxicosis - diagnostic imaging; Thyrotoxicosis - genetics; Ultrasonography
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/402897

Human cardiac β 1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β 1-adrenoreceptors ( β 1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.