Brief case report: A case of FOLFIRI—Induced psychosis

Psychosis may occur due to the FOLFIRI chemotherapy regimen. An exhaustive approach to confounding elements of a patient's medical history should be taken to rule out competing causes of psychosis. Both 5‐FU and Irinotecan may be implicated in psychosis, though which agent in particular is the...

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Bibliographic Details
Published in:Psycho-oncology (Chichester, England) Vol. 32; no. 10; pp. 1625 - 1627
Main Authors: Mukherji, Shamik, Shoaib, Humaira, Jimenez, Xavier
Format: Journal Article
Language:English
Published: Chichester Wiley Subscription Services, Inc 01-10-2023
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Summary:Psychosis may occur due to the FOLFIRI chemotherapy regimen. An exhaustive approach to confounding elements of a patient's medical history should be taken to rule out competing causes of psychosis. Both 5‐FU and Irinotecan may be implicated in psychosis, though which agent in particular is the cause is unclear. Risperidone assisted in resolution of this patient's psychosis whilst Olanzapine and Quetiapine did not. Both 5‐FU and Irinotecan have pharmacologic traits that may induce changes in mental status.
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ISSN:1057-9249
1099-1611
DOI:10.1002/pon.6206