Iontophoretic delivery of oligonucleotide derivatives into mouse tumor

Oligodeoxyribonucleotides (22-mers) were delivered through the skin of C3H mice in the region of a mammary gland tumor by means of iontophoresis. It was shown that the oligonucleotides enter the tumor, cross it, and reach all mouse organs. Electrophoretic analysis of the oligonucleotide extracted fr...

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Bibliographic Details
Published in:	Antisense research and development Vol. 4; no. 4; p. 291
Main Authors:	Vlassov, V V, Nechaeva, M V, Karamyshev, V N, Yakubov, L A
Format:	Journal Article
Language:	English
Published:	United States 1994
Subjects:	Administration, Topical Animals Base Sequence Iontophoresis Mammary Neoplasms, Experimental - drug therapy Mice Mice, Inbred C3H Molecular Sequence Data Oligonucleotides, Antisense - administration & dosage
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Summary:	Oligodeoxyribonucleotides (22-mers) were delivered through the skin of C3H mice in the region of a mammary gland tumor by means of iontophoresis. It was shown that the oligonucleotides enter the tumor, cross it, and reach all mouse organs. Electrophoretic analysis of the oligonucleotide extracted from tumor showed that the compounds were delivered in the tissue in the intact state.
ISSN:	1050-5261
DOI:	10.1089/ard.1994.4.291