Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the in...

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Published in:	Russian journal of bioorganic chemistry Vol. 42; no. 4; pp. 423 - 427
Main Authors:	Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-07-2016
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry inhibitors spermine analogues polyamines spermine oxidase
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Abstract	Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
AbstractList	Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
Author	Grigorenko, N. A. Kochetkov, S. N. Khomutov, A. R. Simonian, A. R. Khomutov, M. A.
Author_xml	– sequence: 1 givenname: N. A. surname: Grigorenko fullname: Grigorenko, N. A. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 2 givenname: M. A. surname: Khomutov fullname: Khomutov, M. A. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 3 givenname: A. R. surname: Simonian fullname: Simonian, A. R. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 4 givenname: S. N. surname: Kochetkov fullname: Kochetkov, S. N. organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences – sequence: 5 givenname: A. R. surname: Khomutov fullname: Khomutov, A. R. email: alexkhom@list.ru organization: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
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Title	Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase
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