Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase

Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the in...

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Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 42; no. 4; pp. 423 - 427
Main Authors:	Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-07-2016
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Life Sciences Organic Chemistry inhibitors spermine analogues polyamines spermine oxidase
Online Access:	Get full text
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Summary:	Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S1068162016030080