Chemoselective N-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles and their anti-microbial activities

• Published in: Medicinal chemistry research Vol. 23; no. 10; pp. 4595 - 4606
• Main Authors: Sneha, Khurana, Jitender M., Sharma, Chetan, Aneja, K. R.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-10-2014
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Original Research; Pharmacology/Toxicology; Ni nanoparticles; 2-Thiohydantoin; Anti-microbial activity; Benzylation; 2-Thiobarbituric acid
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-014-1008-y

An efficient one pot chemoselective
N
-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles has been reported, wherein the NH group of thiohydantoins and thiobarbituric acids is selectively benzylated and no
S
-benzylation is observed. Mildness and environment friendly approach of the protocol gives it an edge over other conventional methods. These compounds were tested in vitro for their antibacterial activity against Gram-positive bacteria namely,
Staphylococcus aureus
and
Bacillus subtilis
and their inhibitory action against two strains of fungus.