Effects of chemotherapy on plasma lipids and lipoproteins in Nigerian patients with haematological malignancy

• Published in: The Nigerian postgraduate medical journal Vol. 18; no. 1; pp. 16 - 19
• Main Authors: Idogun, S E, Omoti, C E
• Format: Journal Article
• Language: English
• Published: Nigeria Wolters Kluwer Medknow Publications 01-03-2011
• Subjects: Adolescent; Adult; Aged; Antineoplastic Agents - therapeutic use; Biomarkers - blood; cardiovascular risk; Female; haematological malignancies; lipids and lipoprotein; Hematologic Neoplasms - drug therapy; Humans; Lipids - blood; Lipoproteins - blood; Male; Middle Aged; Nigeria; Treatment Outcome; Young Adult; Nigeria
• ISSN: 1117-1936; 2468-6875
• DOI: 10.4103/1117-1936.170285

This study is to determine effect of chemotherapy on plasma lipids and lipoproteins in haematological malignancies.
All consecutive patients with haematological malignancies attending University of Benin Teaching Hospital, Benin City, Nigeria between July 2007 and December 2008 were studied. Clinico-pathological types of haematological cancers, demographic features, serum lipid and lipoprotein levels of the patients were analysed, pre and post treatment with chemotherapy.
A total of 28 haematological cancers were studied. Chronic leukemias 10 (35.7%) and lymphomas 7(25.0%),acute leukaemia 6(21.4%), multiple myeloma 4(14.3%), and aplastic anaemia 1(3.6%). The pre therapy median values for TC, TG, LDL-C and HDL-C were 103, 115, 40 and 36mg/dl respectively while the median values for post therapy for TC, TG, LDL-C and HDL-C were 110, 126, 60 and 43 mg/dl respectively. The pre therapy ratio of TC : HDL-C in the patients was 2.4 while the post therapy ratio of TC : HDL-C was 2.7.
Hypocholesterolaemia and hypolipoproteinaemia were seen in our patients when compared with the population reference values and there were no significant changes in lipid and lipoprotein levels between pre and post therapy values.