Thermospermine: An Evolutionarily Ancient but Functionally New Compound in Plants

Themospermine is a structural isomer of spermine and is present in some bacteria and most of plants. An Arabidopsis mutant, acaulis5 (acl5), that is defective in the biosynthesis of thermospermine displays excessive proliferation of xylem vessels with dwarfed growth. Recent studies using acl5 and it...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 1694; p. 51
Main Author:	Takahashi, Taku
Format:	Journal Article
Language:	English
Published:	United States 2018
Subjects:	Biological Evolution Biological Transport Gene Expression Regulation, Plant Plants - genetics Plants - metabolism Spermine - analogs & derivatives Spermine - metabolism uORF Xylem mRNA translation Acaulis5 Thermospermine Arabidopsis
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Summary:	Themospermine is a structural isomer of spermine and is present in some bacteria and most of plants. An Arabidopsis mutant, acaulis5 (acl5), that is defective in the biosynthesis of thermospermine displays excessive proliferation of xylem vessels with dwarfed growth. Recent studies using acl5 and its suppressor mutants that recover the growth without thermospermine have revealed that thermospermine plays a key role in the negative control of the proliferation of xylem vessels through enhancing translation of specific mRNAs that contain a conserved upstream open-reading-frame (uORF) in the 5' leader region.
ISSN:	1940-6029
DOI:	10.1007/978-1-4939-7398-9_4