Brain Abscess Caused by Oral Cavity Bacteria: A Nationwide, Population-based Cohort Study

• Published in: Clinical infectious diseases Vol. 78; no. 3; pp. 544 - 553
• Main Authors: Bodilsen, Jacob, Mariager, Theis, Duerlund, Lærke Storgaard, Storgaard, Merete, Larsen, Lykke, Brandt, Christian Thomas, Hansen, Birgitte Rønde, Wiese, Lothar, Omland, Lars Haukali, Nielsen, Henrik
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 20-03-2024
• Subjects: oral cavity; brain abscess; anaerobic bacteria; cerebral abscess; streptococcus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/cid/ciad678

Abstract
Background
Oral cavity bacteria are the most frequent etiology of brain abscess. Yet, data on the clinical presentation and outcome are scarce.
Methods
We performed a nationwide, population-based study comprising all adults (aged ≥18 years) with brain abscess due to oral cavity bacteria in Denmark from 2007 through 2020. Prognostic factors for unfavorable outcome (Glasgow outcome scale, 1–4) were examined using modified Poisson regression to compute adjusted relative risks (RRs) with 95% confidence intervals (CIs).
Results
Among 287 identified patients, the median age was 58 years (interquartile range, 47–66), and 96 of 287 (33%) were female. Preexisting functional impairment was absent or mild in 253 of 280 (90%), and risk factors for brain abscess included immunocompromise in 95 of 287 (33%), dental infection in 68 of 287 (24%), and ear–nose–throat infection in 33 of 287 (12%). Overall, a neurological deficit was present in 246 of 276 (86%) and in combination with headache and fever in 64 of 287 (22%). Identified microorganisms were primarily the Streptococcus anginosus group, Fusobacterium, Actinomyces, and Aggregatibacter spp., and 117 of 287 (41%) were polymicrobial. Unfavorable outcome occurred in 92 of 246 (37%) at 6 months after discharge and was associated with antibiotics before neurosurgery (RR, 3.28; 95% CI, 1.53–7.04), rupture (RR, 1.89; 95% CI, 1.34–2.65), and immunocompromise (RR, 1.80; 95% CI, 1.29–2.51), but not with specific targeted antibiotic regimens. Identified dental infection was associated with favorable prognosis (RR, 0.58; 95% CI, .36–.93).
Conclusions
Brain abscess due to oral cavity bacteria often occurred in previously healthy individuals without predisposing dental infections. Important risk factors for unfavorable outcome were rupture and immunocompromise. However, outcome was not associated with specific antibiotic regimens supporting carbapenem-sparing strategies.
Brain abscess due to oral cavity bacteria often occurs in healthy individuals for unknown reasons with high risks of unfavorable outcome. Important prognostic factors include rupture of brain abscess and immunocompromise. Targeted antibiotic regimen was not associated with outcome.