The Correlation of the Neutrophil-to-Lymphocyte Ratio With Microvascular Complications in Patients With Diabetes Mellitus

• Published in: Curēus (Palo Alto, CA) Vol. 15; no. 9; p. e44601
• Main Authors: Mahajan, Mayank, Prasad, Manoj Kumar, Ashok, Chanchal, Guria, Rishi Tuhin, Marandi, Sujeet, ., Vidyapati, Subrat, Sudhanshu, Chowdhury, Anindya
• Format: Journal Article
• Language: English
• Published: Palo Alto Cureus Inc 03-09-2023; Cureus
• Subjects: Chi-square test; Diabetes; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Emergency Medicine; Endocrinology/Diabetes/Metabolism; Ethics; Glucose; Hemoglobin; Hyperglycemia; Inflammation; Internal Medicine; Lymphocytes; Neutrophils; Software; Statistical analysis
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.44601

BackgroundHigh neutrophil-to-lymphocyte ratio (NLR) may be used as a reliable measure of vascular complications and an indicator of poor outcomes in cases of diabetes mellitus (DM).MethodsA prospective analytical cross-sectional observational study was conducted at the Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India. A total of 100 patients with DM who met the inclusion and exclusion criteria were included in the study. A pre-tested and semi-structured questionnaire was given to the patients. IBM SPSS software version 26 (IBM Corp., Armonk, NY, USA) and MedCalc trial version 20.114 (MedCalc Software Ltd., Ostend, Belgium) were used for data analysis. Logistic regression analysis was performed to determine the association of the NLR with microvascular complications.ResultsIn our study, the male-to-female ratio was 1.78:1 (male: 64 (n)%, female: 36 (n)%). The mean age of our study population was 56.28 ± 13.24 years. Of 58 patients with microvascular complications, 34 had a high NLR, and 24 patients had a normal NLR. Of 42 patients without microvascular complications, only 14 had a high NLR, and the remaining 28 patients had a normal NLR (p = 0.012). Logistic regression was performed to analyze the association between the NLR and microvascular complications, which demonstrated a significant association (odds ratio (OR): 2.833, 95% confidence interval (CI): 1.238-6.481; p = 0.013).ConclusionsOur study demonstrated the higher odds of having microvascular complications among diabetics with a high NLR compared with non-diabetics. Therefore, the NLR may be used as a measure of microvascular complications in the diabetic population.