An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This resp...

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 45; no. 33; p. 13021
Main Authors:	Chow, Sun Y S, Lo, Pui-Chi, Ng, Dennis K P
Format:	Journal Article
Language:	English
Published:	England 16-08-2016
Subjects:	Cell Line, Tumor Cell Survival - drug effects Fluorescence Fluorescent Dyes - administration & dosage Fluorescent Dyes - chemistry Humans Indoles - administration & dosage Indoles - chemistry Photochemotherapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Singlet Oxygen - chemistry Zinc - administration & dosage Zinc - chemistry
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Summary:	An acetal-linked self-quenched zinc(ii) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.
ISSN:	1477-9234
DOI:	10.1039/c6dt02283a