Strongyloides‐specific IgA, IgG and IgG immune complex profile in patients with pulmonary tuberculosis

• Published in: Parasite immunology Vol. 43; no. 1; pp. e12793 - n/a
• Main Authors: Bosqui, Larissa Rodrigues, Silva, Gabriela Borges, Gonzaga, Henrique Tomaz, Gonçalves, Ana Lúcia Ribeiro, Custodio, Luiz Antonio, Pavanelli, Wander Rogério, Conchon‐Costa, Ivete, Paula, Fabiana Martins, Costa‐Cruz, Julia Maria, Costa, Idessania Nazareth
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-01-2021
• Subjects: Adult; Animals; Antibodies; Antibodies, Protozoan - blood; Antibody response; Antigen-Antibody Complex - blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; immune complex; immunodiagnosis; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin G; Immunoglobulin G - blood; Larva - immunology; Male; Middle Aged; Optical density; Saliva; Saliva - immunology; Strongyloides; Strongyloides - immunology; Strongyloidiasis; Strongyloidiasis - immunology; Strongyloidiasis - pathology; Tuberculosis; Tuberculosis, Pulmonary - pathology; saliva; immunodiagnosis; strongyloidiasis; immune complex; tuberculosis
• ISSN: 0141-9838; 1365-3024
• DOI: 10.1111/pim.12793

Aims
To describe an anti‐Strongyloides IgA, IgG and IgG immune complex antibody response profile in patients with pulmonary tuberculosis.
Methods and Results
Saliva and serum samples were collected from 100 individuals: group I, 50 apparently healthy individuals; and group II, 50 pulmonary tuberculosis patients. The IgA, IgG and IgG immune complex detection were carried out via an ELISA immunoenzymatic test. Optical density medians in saliva samples of IgA antibody (median of 7.21) and IgG‐IC (median of 4.95) were significantly higher in tuberculosis group compared to control individuals (median IgA of 3.93 and IgG‐IC of 2.38).
Conclusion
This study presents antibody data to the field of pulmonary tuberculosis and strongyloidiasis coinfection, including saliva samples, and especially IgG immune complex detection.