Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera

• Published in: Chemical papers Vol. 77; no. 7; pp. 3603 - 3617
• Main Authors: Pandey, Pradeep Kumar, Gangwar, Chinky, Yaseen, Bushra, Kumar, Indresh, Nayak, Rashmi, Kumar, Saurabh, Naik, Radhey Mohan, Banerjee, Monisha, Sarkar, Joy
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-07-2023
• Subjects: Biochemistry; Biotechnology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Industrial Chemistry/Chemical Engineering; Materials Science; Medicinal Chemistry; Original Paper; Green synthesis; Anticancerous activity; DPPH assay; Silver nanoparticles
• ISSN: 0366-6352; 1336-9075; 2585-7290
• DOI: 10.1007/s11696-023-02723-5

Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant
Blumea lacera (B. lacera).
The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC
50
or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via
B. lacera
possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to
B. lacera
plant leaves. The minimal inhibition concentration (IC
50
) of ~ 6 μg/mL for synthesized AgNPs was found.
Graphical abstract