When to randomize patients in a randomized controlled trial?

The timing of randomization should be considered carefully in the context of each trial because it has implications for the particular research question answered. In most instances, randomization should be delayed until as close as practically possible to the moment of intervention. In some cases, e...

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Bibliographic Details
Published in:	Fertility and sterility Vol. 121; no. 6; pp. 902 - 904
Main Authors:	Lensen, Sarah, Sydes, Matthew R., Polyakov, Alex, Wilkinson, Jack
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2024
Subjects:	Female Humans methodology Patient Selection Randomization Randomized Controlled Trials as Topic - methods RCT Research Design Time Factors Randomization RCT methodology
Online Access:	Get full text
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Summary:	The timing of randomization should be considered carefully in the context of each trial because it has implications for the particular research question answered. In most instances, randomization should be delayed until as close as practically possible to the moment of intervention. In some cases, early randomization may offer certain advantages, but trialists should balance these, including any administrative complexity or inconvenience, against the risk of avoidable protocol violations and avoidable drop out.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2024.03.008