Therapy-related acute myeloid leukemia following postoperative adjuvant chemotherapy including cisplatin and fluorouracil for esophageal carcinoma

• Published in: Esophagus : official journal of the Japan Esophageal Society Vol. 10; no. 3; pp. 174 - 178
• Main Authors: Manabe, Masahiro, Kosaka, Kinshi, Nakano, Hirofumi, Takakuwa, Teruhito, Harada, Naonori, Okamoto, Shuichiro, Aoyama, Yasutaka, Kumura, Takeo, Ohta, Tadanobu, Furukawa, Yoshio, Takeuchi, Kazuhiro, Mugitani, Atsuko
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-09-2013; Springer Nature B.V
• Subjects: Case Report; Case reports; Chemotherapy; Esophageal cancer; Esophagus; Gastroenterology; Leukemia; Medical diagnosis; Medicine; Medicine & Public Health; Postoperative period; Surgical Oncology; Thoracic Surgery; Throat surgery; Tumors; Esophageal carcinoma; Therapy-related myeloid neoplasms; Cisplatin; Fluorouracil
• ISSN: 1612-9059; 1612-9067
• DOI: 10.1007/s10388-013-0366-8

We report a case of therapy-related acute myeloid leukemia (t-AML), which developed following chemotherapy involving cisplatin and 5-fluorouracil for esophageal carcinoma. A 70-year-old man with past history of esophageal carcinoma, which was treated with subtotal esophagectomy 32 months earlier followed by 2 courses of chemotherapy involving cisplatin and 5-fluorouracil, was diagnosed with t-AML. His leukemia was resistant to chemotherapy, and the patient died from pneumonia 4 months after being diagnosed with leukemia. Although treatment for esophageal carcinoma is associated with a markedly lower frequency of therapy-related myeloid neoplasms than treatment for certain other malignancies such as hematological neoplasms, it is important to be aware that therapy-related myeloid neoplasms can occur as late complications of esophageal carcinoma treatment.