Signaling in the stem cell niche: regulating cell fate, function and plasticity

Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-reside...

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Published in:	Development (Cambridge) Vol. 145; no. 15
Main Authors:	Chacón-Martínez, Carlos Andrés, Koester, Janis, Wickström, Sara A
Format:	Journal Article
Language:	English
Published:	England 01-08-2018
Subjects:	Niche Skin Epithelium Intestine Lung Stem cells
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Abstract	Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis and regeneration, and highlight how these diverse inputs influence stem cell plasticity.
AbstractList	Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis and regeneration, and highlight how these diverse inputs influence stem cell plasticity.
Author	Koester, Janis Wickström, Sara A Chacón-Martínez, Carlos Andrés
Author_xml	– sequence: 1 givenname: Carlos Andrés surname: Chacón-Martínez fullname: Chacón-Martínez, Carlos Andrés organization: Paul Gerson Unna Group 'Skin Homeostasis and Ageing', Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany – sequence: 2 givenname: Janis surname: Koester fullname: Koester, Janis organization: Paul Gerson Unna Group 'Skin Homeostasis and Ageing', Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany – sequence: 3 givenname: Sara A surname: Wickström fullname: Wickström, Sara A email: sara.wickstrom@helsinki.fi organization: Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30068689$$D View this record in MEDLINE/PubMed
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Snippet	Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional,...
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Title	Signaling in the stem cell niche: regulating cell fate, function and plasticity
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