Signaling in the stem cell niche: regulating cell fate, function and plasticity

Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-reside...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 145; no. 15
Main Authors:	Chacón-Martínez, Carlos Andrés, Koester, Janis, Wickström, Sara A
Format:	Journal Article
Language:	English
Published:	England 01-08-2018
Subjects:	Niche Skin Epithelium Intestine Lung Stem cells
Online Access:	Get full text
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Summary:	Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells have traditionally been applied to tissue-resident stem cells. However, accumulating evidence implicates stemness as a bidirectional, dynamic state that is largely governed by the niche, which facilitates plasticity and adaptability to changing conditions. In this Review, we discuss mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis and regeneration, and highlight how these diverse inputs influence stem cell plasticity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0950-1991 1477-9129
DOI:	10.1242/dev.165399