Cerium oxide nanoparticles via gel-combustion for electrochemical investigation of pantoprazole in the presence of epinephrine

• Published in: Journal of materials science. Materials in electronics Vol. 33; no. 23; pp. 18374 - 18388
• Main Authors: Pradeepa, E., Nayaka, Y. Arthoba
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-08-2022; Springer Nature B.V
• Subjects: Carbon; Cerium oxides; Characterization and Evaluation of Materials; Chemistry and Materials Science; Combustion; Electrochemical oxidation; Electrodes; Electron microscopy; Energy dispersive X ray analysis; Epinephrine; Fourier transforms; Infrared analysis; Infrared spectroscopy; Materials Science; Microscopy; Nanoparticles; Optical and Electronic Materials; Stability analysis; Voltammetry; X ray analysis
• ISSN: 0957-4522; 1573-482X
• DOI: 10.1007/s10854-022-08692-x

In this work, cerium oxide nanoparticles (CeO
2
NPs) were prepared by naturally available Aloe-Vera (AV) gel as fuel via gel-combustion technique (GCT). Obtained CeO
2
NPs were blended with graphite powder to produce cerium oxide fabricated carbon paste electrode (CeO
2
/CPE) and used for the detection of pantoprazole (PPZ). Surface features of CeO
2
NPs were premeditated by X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), Brunauer–Emmett–Teller (BET) measurement, and transmission electron microscopy (TEM). The modified CeO
2
/CPE gives notable current enhancement compared to the bare carbon paste electrode (BCPE) during electrochemical oxidation of pantoprazole (PPZ) in 0.1 M PBS of pH 7. The behaviour of PPZ was studied in presence of epinephrine (EPN) at modified CeO
2
/CPE. The influence of modifiers, effect of pH, scan rate, and concentration of PPZ has been studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The effect of PPZ concentration has been studied by DPV technique in the range of 2–5.5 µM, with a detection limit of 0.371 µM L
−1
. The modified sensor was also used for the real sample analysis of drug present in a pharmaceutical sample. Stability, sensitivity, and limit of detection for the analysis of PPZ indicated the potentiality of modified CeO
2
/CPE.