High surface area mesoporous BiZnSbV-G-SiO2 -based electrochemical biosensor for quantitative and rapid detection of microalbuminuria

• Published in: Journal of applied electrochemistry Vol. 51; no. 9; pp. 1345 - 1360
• Main Authors: Fatema, Kamrun Nahar, Lim, Chang Sung, Oh, Won-Chun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-09-2021; Springer Nature B.V
• Subjects: Ascorbic acid; Biosensors; Chemistry; Chemistry and Materials Science; Control equipment; Electrical resistivity; Electrochemical analysis; Electrochemistry; Graphene; Industrial Chemistry/Chemical Engineering; Low cost; Morphology; Nanocomposites; Physical Chemistry; Research Article; Selectivity; Sensors; Silicon dioxide; Synergistic effect; Uric acid; Urine; Electrochemical performance; Microalbumin; Graphene composite; Biosensor; Mesoporosity
• ISSN: 0021-891X; 1572-8838
• DOI: 10.1007/s10800-021-01576-8

In this work, we synthesized a mesoporous BiZnSbV-G-SiO
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electrode-based sensor to detect microalbumin in urine, due to graphene based sensor system has a high electrocatalytic movement, electrical conductivity, abundance, and low cost. The synergistic effects of BiZnSbV-G-SiO
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nanocomposites advanced the electrochemical reaction and the affectability of the sensor. The synthesized active materials were characterized with surface morphology techniques, electron behavior controlling spectroscopy and electrochemical performance instrument, individually. Especially, chronoamperometric electrochemical evaluation system was used for the quantitative detection of microalbumin. We did electrochemical evaluations with a few possible compounds that regularly appear in urine (ascorbic acid, uric acid, glucose), which showed the good sensitivity and selectivity for the microalbumin detection. Under ideal conditions, the sensor can distinguish urinary microalbumin in a wide straight run from 0.01 to 0.1 μl with a location constraint of 0.01 μl. The excellent sensing performance of the mesoporous BiZnSbV-G-SiO
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active material was confirmed by analyzing microalbumin obtained from urine. The biosensor proposed here is specified in terms of simplification, low-cost, quick response, and precise screening for the microalbuminuria detection. This approach gives a promising stage for creating clinical point-of-care demonstrative applications. Additionally, the manufactured sensor had good selectivity, great reproducibility, great soundness, and good recuperation, which showed potential for applications in the clinical field.
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