Nanogels as controlled drug release systems for Coenzyme Q10 and Resveratrol for cosmetic application

• Published in: Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 23; no. 8
• Main Authors: Arroyo, E., Valdez, R., Cornejo-Bravo, J. M., Armenta, M. A., Olivas, A.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-08-2021; Springer Nature B.V
• Subjects: Addition polymerization; Aging; Antioxidants; Bioassays; Biocompatibility; Characterization and Evaluation of Materials; Chemistry and Materials Science; Coenzyme Q10; Drug carriers; Drug delivery; Drug delivery systems; Drugs; Encapsulation; Gene expression; Hydrophobicity; Inorganic Chemistry; Lasers; Materials Science; Morphology; Nanoparticles; Nanotechnology; Optical Devices; Optics; Permeability; Photomicrographs; Photonics; Physical characteristics; Physical Chemistry; Physicochemical properties; Polyethylene glycol; Polyvinylpyrrolidone; Radiation; Research Paper; Resveratrol; Signal transduction; Skin; Skin temperature; Nanogels; Drug delivery; Antioxidant; Polymers; Coenzyme Q10; Resveratrol
• ISSN: 1388-0764; 1572-896X
• DOI: 10.1007/s11051-021-05243-z

Polymeric nanogels have been widely used as drug carrier systems due to their high drug loading capacity and an improved solubility of hydrophobic drugs. Many studies have shown that hydrophobic antioxidants, such as CoQ10 or Resveratrol, might improve healthy skin and be an effective anti-aging treatment by repairing photo-damaged skin. This study was carried out to develop a delivery system based on bio-compatible and water-dispersible nanogels capable of encapsulating Coenzyme Q10 (CoQ10) and Resveratrol. The nanogels are based on Pluronic® P123 coated with polyvinylpyrrolidone plus polyethyleneglycol (P123/PVP-PEG). Their physicochemical properties and morphological characteristics were evaluated in detail, as well as in vitro drug release. These nanogels were able to encapsulate and release Resveratrol and CoQ10 better than pure drugs at skin temperature (32 °C), from 31 to 43 and from 25 to 40%, respectively. The systems exhibited nanometric dimensions and spherical shape shown in the SEM and HRTEM micrographs. The bacterial bioassays studies showed that loaded materials do not affect bacterial growth. In addition, aqueous polymeric dispersions were stable for at least 24 h. The results indicated that the prepared nanogels were water-dispersible, non-toxic in the first tests, and they could be potential candidates for hydrophobic antioxidant release.
Graphical abstract