Microbiological and clinical comparison of chlorhexidine buccoadhesive tablet and chlorhexidine mouthrinse

• Published in: Journal of drug delivery science and technology Vol. 19; no. 5; pp. 353 - 357
• Main Authors: Aktaş, A., Giray, B., Çapan, Y., Menemenlioğlu, D., Hayran, M., İkinci, G., Vural, İ.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier B.V 2009; Editions de santé
• Subjects: Biological and medical sciences; Buccoadhesive Tablet; Chlorhexidine; Controlled release; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Chlorhexidine; Controlled release; Buccoadhesive Tablet; Buccoadhenive Tablet; Biguanides; Pharmaceutical technology; Controlled release form; Antiseptic; Dosage form; Guanidines; Tablet; Disinfecting agent; Comparative study
• ISSN: 1773-2247
• DOI: 10.1016/S1773-2247(09)50073-1

Chlorhexidine, which is a gold standard for antiplaque agents, was prepared as a buccoadhesive controlled-release drug formulation. The released amount and effectiveness of the antibacterial properties of the formulations were determined in in vivo and in vitro studies. In laboratory studies, nearly 40% of the total amount of the drug was released over 4 h. Clinically, first day results up to 4 h showed a statistically significant reduction of the bacterial amount in the drug-loaded side of oral mucosa. The results for 1 and 4 days were not statistically significant in the tablet group. The usefulness of the tablet dosage form was also assessed in the subjects.