The Use of Fluor-Hydroxy Pulse Peel in Actinic Porokeratosis

• Published in: Dermatologic surgery Vol. 31; no. 9; pp. 1145 - 1148
• Main Authors: TEIXEIRA, SOLANGE P, DE NASCIMENTO, MAURÍCIO M, BAGATIN, EDILÉIA, HASSUN, KARIME M, TALARICO, SÉRGIO, MICHALANY, NILCEO
• Format: Journal Article
• Language: English
• Published: Malden, MA by the American Society for Dermatologic Surgery, Inc 01-09-2005; Blackwell
• Subjects: Biological and medical sciences; Biopsy; Chemexfoliation - methods; Dermatology; Dyskeratosis; Female; Fluorouracil - therapeutic use; Glycolates - therapeutic use; Humans; Injuries of the skin. Diseases of the skin due to physical agents; Keratolytic Agents - therapeutic use; Medical sciences; Middle Aged; Porokeratosis - drug therapy; Porokeratosis - etiology; Skin - pathology; Skin plastic surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Traumas. Diseases due to physical agents; Ultraviolet Rays - adverse effects; Human; Dyskeratosis; Photosensitivity; Skin disease; Dermatology; Hyperkeratosis; Genetic disease; Case study; Photodermatosis; Skin peeling; Treatment; Surgery; Actinic porokeratosis
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1097/00042728-200509000-00013

BACKGROUNDThe use of Fluor-Hydroxy pulse peel (Drogaderma, Sao Paulo, Brazil) was reported by Katz to treat solar damage and actinic keratosis–associated lesions.1,2
OBJECTIVEThe objective was to use this combined treatment to produce therapeutic and cosmetic benefits in a patient with actinic porokeratosis.
METHODSA case of actinic disseminated porokeratosis was treated with a combination of a 70% glycolic peel and a 5% 5-fluorouracil solution (Drogaderma) every 2 weeks for 4 months. A biopsy was done before and after eight treatment pulses.
RESULTSImprovement in the appearance and texture of the treated areas and decreased dyskeratosis and epidermal atypia.
CONCLUSIONThe Fluor-Hydroxy pulse peel can be an effective alternative for the treatment of actinic porokeratosis.