Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience
Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis. To examine risk factors for dyslipidemia in young subjects with T1D. Longitudinal and cross-se...
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| Published in: | World journal of diabetes Vol. 12; no. 1; pp. 56 - 68 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Baishideng Publishing Group Inc
15-01-2021
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis.
To examine risk factors for dyslipidemia in young subjects with T1D.
Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D (86 males; baseline mean age 12.2 ± 5.6 years and hemoglobin A1c 8.4% ± 1.4%) were followed in a single tertiary diabetes center for a median duration of 15 years. Predictors for outcomes of lipid profiles at last visit (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein-cholesterol [LDL-c], and high-density lipoprotein-cholesterol [HDL-c]) were analyzed by stepwise linear regression models.
At baseline, 79.5% of the patients had at least one additional CVD risk factor (borderline dyslipidemia/dyslipidemia [37.5%], pre-hypertension/hypertension [27.6%], and overweight/obesity [16.5%]) and 41.6% had multiple (≥ 2) CVD risk factors. A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1% of the cohort. Predictors of elevated TC: family history of CVD (β[SE] = 23.1[8.3],
= 0.006); of elevated LDL-c: baseline diastolic blood pressure (DBP) (β[SE] = 11.4[4.7],
= 0.003) and family history of CVD (β[SE] = 20.7[6.8],
= 0.017); of elevated TGs: baseline DBP (β[SE] = 23.8[9.1],
= 0.010) and family history of CVD (β[SE] = 31.0[13.1],
= 0.020); and of low HDL-c levels: baseline DBP (β[SE] = 4.8[2.1],
= 0.022]).
Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD. It is of utmost importance to prevent and control modifiable risk factors such as these, as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Krepel Volsky S contributed to the data used in the study, searched the literature, interpreted the data, and wrote the initial draft of the manuscript; Shalitin S, Fridman E, Lazar L, Bello R, Oron T, Tenenbaum A, and de Vries L contributed to the data used in this article, contributed to the discussion, and reviewed and edited the manuscript; Yackobovitch-Gavan M analyzed and interpreted the data, contributed to the discussion, and reviewed and edited the manuscript; Lebenthal Y designed the study, contributed to the data used in this article, contributed to the discussion, and reviewed and edited the manuscript; Krepel Volsky S is the guarantor of this work, and thus had full access to all of the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis; All authors approved the final version. Corresponding author: Shlomit Shalitin, MD, Professor, National Center for Childhood Diabetes, The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petach-Tikva 4920235, Israel. shlomits2@clalit.org.il |
| ISSN: | 1948-9358 1948-9358 |
| DOI: | 10.4239/wjd.v12.i1.56 |