Drug eluting biliary stents to decrease stent failure rates: A review of the literature

Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use...

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Published in:World journal of gastrointestinal endoscopy Vol. 8; no. 2; pp. 77 - 85
Main Authors: Shatzel, Joseph, Kim, Jisoo, Sampath, Kartik, Syed, Sharjeel, Saad, Jennifer, Hussain, Zilla H, Mody, Kabir, Pipas, J Marc, Gordon, Stuart, Gardner, Timothy, Rothstein, Richard I
Format: Journal Article
Language:English
Published: United States Baishideng Publishing Group Inc 25-01-2016
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Summary:Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy.
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Correspondence to: Joseph Shatzel, MD, Section of Hematology-Oncology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, United States. joseph.j.shatzel@hitchcock.org
Author contributions: All authors contributed equally to the work, researched the topic and wrote the review.
Telephone: +1-603-6508380 Fax: +1-603-6506122
ISSN:1948-5190
1948-5190
DOI:10.4253/wjge.v8.i2.77