Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms

• Published in: Bioscience journal Vol. 34; no. 4; pp. 1017 - 1024
• Main Authors: Guedes, Clarice Moura, Santos, Fabelina Karollyne Silva dos, Silva, Tamires, Silva, Ana Paula Soares e, Lima, Michele Vieira da Silva, Oliveira, Valtânia Ana de, Silva, Maria Eduarda Sousa, Abreu, Maria Carolina de, Peron, Ana Paula Paula
• Format: Journal Article
• Language: English
• Published: Universidade Federal de Uberlândia 01-07-2018
• Subjects: Cell division; Cellular changes; Excipients; Ginkgo; Meristematic tissue
• ISSN: 1981-3163; 1981-3163
• DOI: 10.14393/BJ-v34n1a2018-39745

The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used.