Computed Tomography Fractional Flow Reserve to Guide Coronary Angiography and Intervention

• Published in: Interventional cardiology clinics Vol. 7; no. 3; pp. 345 - 354
• Main Authors: Mathew, Roshin C., MS, MD, Gottbrecht, Matthew, MD, Salerno, Michael, MD, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands 01-07-2018
• Subjects: Cardiovascular; Computed Tomography Angiography - methods; Coronary Angiography - methods; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - surgery; Coronary Vessels - diagnostic imaging; Epidemiologic Methods; Fractional Flow Reserve, Myocardial - physiology; Humans; Percutaneous Coronary Intervention - methods; Fractional flow reserve (FFR); Coronary computed tomography angiography (CTA); Coronary artery disease; CT-FFR
• ISSN: 2211-7458; 2211-7466; 2211-7466
• DOI: 10.1016/j.iccl.2018.03.008

Computed tomography angiography (CTA) has played a significant role in evaluation of coronary artery disease in the last decade and has demonstrated high sensitivity and negative predictive values. However, the positive predictive value as compared with invasive fractional flow reserve (FFR) is limited. CT-FFR has emerged as a disruptive noninvasive technology with higher specificity and diagnostic accuracy for detection of hemodynamically significant coronary lesions as compared with invasive FFR than conventional coronary CTA. CT-FFR has been shown to be cost-effective as a gate-keeper to invasive coronary angiography and has the potential to limit unnecessary invasive angiography studies.