2‐Chloro‐5‐(1‐hydroxy‐3‐oxoisoindolin‐1‐yl)benzenesulfonamides as potential inhibitors of urease: Synthesis, in‐vitro and molecular modeling approach

• Published in: Journal of the Chinese Chemical Society (Taipei) Vol. 69; no. 10; pp. 1810 - 1819
• Main Authors: Irshad, Sajid, Ahmad, Saeed, Khan, Mohsin Abbas, Aziz, Mubashir, Ejaz, Syeda Abida, Elhadi, Muawya
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01-10-2022; Wiley Subscription Services, Inc
• Subjects: Chemical synthesis; gastric and peptic ulcer; GIT disorders virulent bacteria's; Imines; Inhibitors; Peptic ulcers; Schiff base; urease; urease inhibitor
• ISSN: 0009-4536; 2192-6549
• DOI: 10.1002/jccs.202200295

The present work is focused on the identification of 2‐chloro‐5‐(1‐hydroxy‐3‐oxoisoindolin‐1‐yl) benzenesulfonamides (5a–5k) Schiff bases as potent urease inhibitors. The rationale behind the urease activity was to introduce lead candidate for the treatment of GIT disorders including gastric and peptic ulcer and hepatic encephalopathy. The synthesized compounds exhibited excellent anti‐urease activity which was further supported by in‐silico investigations. Therefore, it can be suggested that these derivatives can be considered as a potential lead in future for synthesis of potent inhibitors.
Schiff bases as the potential inhibitors of urease enzyme.