Topical difluprednate for treatment of serous retinal detachment and panuveitis associated with Vogt-Koyanagi-Harada disease

• Published in: Digital journal of ophthalmology Vol. 22; no. 2; pp. 54 - 57
• Main Authors: Lu, Stacey, Taban, Mehran
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Eye and Ear Infirmary 2016
• Subjects: Case Report; Fluorescein Angiography; Fluprednisolone - administration & dosage; Fluprednisolone - analogs & derivatives; Fundus Oculi; Glucocorticoids - administration & dosage; Humans; Intravitreal Injections; Male; Middle Aged; Ophthalmic Solutions; Panuveitis - diagnosis; Panuveitis - drug therapy; Panuveitis - etiology; Retinal Detachment - diagnosis; Retinal Detachment - drug therapy; Retinal Detachment - etiology; Tomography, Optical Coherence; Uveomeningoencephalitic Syndrome - complications; Uveomeningoencephalitic Syndrome - diagnosis; Visual Acuity
• ISSN: 1542-8958; 1542-8958
• DOI: 10.5693/djo.02.2015.05.004

Patients with bilateral serous retinal detachments and panuveitis related to Vogt-Koyanagi-Harada disease are commonly managed with oral corticosteroids, immunosuppressive agents, and/or intravitreal injections. We present the case of a 56-year-old Hispanic man with Harada disease whose bilateral serous retinal detachments and panuveitis were treated with topical corticosteroid difluprednate alone. Functional and anatomical recoveries were assessed by fluorescein angiograms and optical coherence tomography studies over a period of 9 months. The patient's serous retinal detachments resolved, and his vision and panuveitis improved dramatically over a period of 2 weeks, after which he was placed on a drop taper and maintenance therapy for the remainder of the 9 months.