A Photo‐Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing

• Published in: Advanced functional materials Vol. 32; no. 51
• Main Authors: Lu, Mingzhu, Li, Shanshan, Xiong, Xiaolu, Huang, Zhijun, Xu, Bolong, Liu, Yunhang, Wu, Qingyuan, Wu, Nier, Liu, Huiyu, Zhou, Dongsheng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01-12-2022
• Subjects: Antibiotics; Bacteria; Carbon; Disinfection; Dopamine; Electron transport; Hydrogen peroxide; Hydroxyl radicals; Manganese; Materials science; multi‐drug resistant bacteria; Nanospheres; nanozymes; Peroxidase; photothermal effects; Superoxide dismutase; wound disinfection; Wound healing
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.202208061

The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnOx/HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnOx/HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O2•−), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH). Importantly, near‐infrared light facilitates the electron transport of MnOx/HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnOx/HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnOx/HNCS in the MDR bacteria‐infected wound model. Notably, MnOx/HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform.
This study reports a photo‐responsive therapeutic platform, which combines photothermal therapy and photo‐enhanced catalytic therapy to kill multi‐drug resistant bacteria and suppresses further inflammation. Mn2+ released from this nanoparticle and mild heat generated from its photothermal effect play important roles in wound healing by stimulating extracellular matrix disposition and reepithelialization.