Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide ( 8e ) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazol...

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Published in:Medicinal chemistry research Vol. 26; no. 10; pp. 2568 - 2582
Main Authors: Divya, Kuppi Reddy Gari, Sowmya, Donthamsetty V., Durgamma, Suram, Tharanath, Vadlamudi, Gopal, Divi Venkataramana Sai, Kumar, Malaka Venkateshwarulu Jyothi, Appa Rao, Chippada, Padmaja, Adivireddy, Padmavathi, Venkatapuram
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2017
Springer Nature B.V
Subjects:
Acetic acid
Antioxidants
Antiviral activity
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell lines
Original Research
Pharmacology/Toxicology
Tongue
Viruses
Azoles
Pyrimidines
Antioxidant activity
Antiviral activity
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Summary:A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide ( 8e ) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides ( 8b , 8e ) exhibited antiviral activity on BHK 21 cell lines with IC 50 63.5, 44.5 µg/mL, respectively. The compound 8e inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-1956-0