Properties of Langmuir and immobilized layers of betulin diphosphate on aqueous solutions of zinc sulfate and on the surface of zinc oxide nanoparticles

• Published in: Russian chemical bulletin Vol. 70; no. 2; pp. 289 - 300
• Main Authors: Melnikova, N. B., Malygina, D. S., Vorobyova, O. A., Solovyeva, A. G., Belyaeva, K. L., Orekhov, D. V., Knyazev, A. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-02-2021; Springer Nature B.V
• Subjects: Anticancer properties; Aqueous solutions; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Compressibility; Full Articles; Infrared spectroscopy; Inorganic Chemistry; Nanoparticles; Organic Chemistry; Substrates; Wound healing; Wurtzite; Zinc oxide; Zinc oxides; immobilization; zinc oxide nanoparticles; Langmuir monolayers; betulin diphosphate
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-021-3084-8

This work examines the specific features of interaction of betulin diphosphate (BDP), exhibiting antitumor and wound-healing properties, with zinc cations during its immobilization on ZnO nanoparticles. The properties of Langmuir and transferred BDP monolayers from an aqueous subphase of zinc sulfate onto the surface of a solid substrate (CaF
2
, quartz) by the Langmuir—Schaefer method are investigated using IR and UV spectroscopy. It is shown that there is a twofold increase of the molecular area in the immobilized layers, while the compressibility modulus decreases by a factor of 1.5. Zinc oxide nanoparticles with immobilized BDP 10–20 nm in size (surface concentration of BDP is 100 mg g
−1
) retain the original hexagonal wurtzite structure. The efficiency of betulin diphosphate immobilized on the surface of zinc oxide nanoparticles is demonstrated in
in vivo
experiments for burn wounds in rats.