Effect of yttrium on calcium-dependent processes in vertebrate myocardium

• Published in: Journal of evolutionary biochemistry and physiology Vol. 50; no. 3; pp. 221 - 226
• Main Authors: Shemarova, I. V., Sobol’, K. V., Korotkov, S. M., Nesterov, V. P.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-05-2014; Springer Nature B.V
• Subjects: Animal Physiology; Biochemistry; Biomedical and Life Sciences; Comparative and Ontogenic Biochemistry; Evolutionary Biology; Frogs; Heart; Life Sciences; Mitochondria; Trace elements; Vertebrates; inotropic effect; mitochondria; contraction; Y; myocardium; swelling; rare earth metals; Ca; vertebrates
• ISSN: 0022-0930; 1608-3202
• DOI: 10.1134/S0022093014030041

Inoptopic effect of yttrium acetate (Y
3+
) on myocardium of the marsh frog
Rana ridibunda
and its effect on ion transport across the inner mitochondrial membrane (IMM) of rat heart was studied. Y
3+
was found to decrease the rate of heart contractions and to stimulate ion transport in the rat heart mitochondria in media with 10 mM glutamate and 2 mM malate. Presence of Y
3+
induced inhibition of energy-dependent Ca
2+
transport into mitochondria, which was expressed as a marked decrease of their swelling in the media containing 125 mM NH
4
NO
3
and Ca
2+
or 25 mM potassium acetate, 100 mM sucrose and Ca
2+
. It is suggested that the Y
3+
-induced decrease in rat muscle contractions is determined not only by direct suppressing effect of Y
3+
on potential-modulated Ca
2+
-channels of pacemaker and contractile cardiomyocytes (CM), but also by its indirect effect on Ca
2+
-carrier in IMM. The data confirming that Y
3+
activates energy-dependent K
+
transport catalyzed by mitochondrial uniporter and blocks Ca
2+
-channels in the mitochondrial membrane are important for more complete understanding of mechanisms of the Y
3+
action on vertebrates and human CM.