Adrenal cortex in peripubertal and adult female rats after neonatal treatment with SRIH-14

• Published in: Archives of biological sciences Vol. 60; no. 1; pp. 41 - 47
• Main Authors: Milosevic, V., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia), Terzic, M., University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Physiology, Filipovic, B, Manojlovic, M, Sosic-Jurjevic, B, Sekulic, M., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia), Starcevic, V., University of Belgrade, Belgrade (Serbia). School of Medicine, Institute of Physiology
• Format: Journal Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2008
• Subjects: ADRENAL GLANDS; female rats; FEMALES; FEMELLE; GLANDULAS SUPRARRENALES; HEMBRA; http://www.fao.org/aos/agrovoc#c_135; http://www.fao.org/aos/agrovoc#c_15969; http://www.fao.org/aos/agrovoc#c_26877; http://www.fao.org/aos/agrovoc#c_6464; neonatal period; RAT; RATA; RATS; SOMATOSTATIN; SOMATOSTATINA; SOMATOSTATINE; SURRENALE; zona fasciculata; zona glomerulosa; zona reticularis
• ISSN: 0354-4664; 1821-4339
• DOI: 10.2298/ABS0801041M

Neonatal female rats (3-7 days old) were injected subcutaneously twice daily with 20 microgram of SRIH-14/100 g b.w. for five consecutive days. The animals were sacrified in the peripubertal (38 days old) or adult (80 days old) periods of life. From the results, it can be concluded that subcutaneously applied SRIH-14 in the neonatal period inhibits growth of adrenal ZG (zona glomeruloza) cells in female rats only up to the peripubertal stage, while the adrenal gland cortex recovers before mature adulthood is reached.