Mechanistic Insights into TiO2 and ZnO Nanoparticle-Induced Metabolic Changes in Escherichia coli Under Solar Simulated Light Irradiation

• Published in: Water, air, and soil pollution Vol. 231; no. 1
• Main Authors: Pathakoti, Kavitha, Manubolu, Manjunath, Hwang, Huey-min
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2020; Springer Nature B.V
• Subjects: Adaptation; Arginine; Atmospheric Protection/Air Quality Control/Air Pollution; Cells; Climate Change/Climate Change Impacts; E coli; Earth and Environmental Science; Environment; Environmental monitoring; Glycine; Glycine (amino acid); Hydrogeology; Irradiation; Light effects; Light irradiation; Metabolic pathways; Metabolic response; Metabolism; Metabolites; Multivariate analysis; Nanoparticles; Oxidative stress; Polyamines; Proline; Putrescine; Serine; Soil Science & Conservation; Threonine; Titanium dioxide; Water Quality/Water Pollution; Zinc oxide; Nanoparticles; Multivariate analyses; ZnO; TiO; Metabolite profiling; Untargeted metabolomics
• ISSN: 0049-6979; 1573-2932
• DOI: 10.1007/s11270-019-4388-2

This study investigated the metabolic response of
E. coli
after exposure to TiO
2
and ZnO NPs under solar simulated irradiation. A total of 14 altered metabolites involved in two metabolic pathways were recognized using multivariate analysis. Polyamine, putrescine was elevated in ZnO-treated group, as an adaptation to oxidative stress in cells, whereas it was significantly reduced in TiO
2
-treated group. Glycine levels also were elevated in both the treatment groups, showing cellular protection in cells after exposure. In addition, glycine, serine, and threonine metabolism and arginine and proline metabolism were altered in ZnO and TiO
2
-treated groups respectively.