Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

• Published in: Research on chemical intermediates Vol. 43; no. 1; pp. 187 - 202
• Main Authors: Archana, Sivasubramaniyan, Dinesh, Murugan, Ranganathan, Raja, Ponnuswamy, Alagusundaram, Kalaiselvi, Patchaiah, Chellammal, Subbiah, Subramanian, Gopalan, Murugavel, Saminathan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 2017; Springer Nature B.V
• Subjects: Ammonium acetate; Antiinfectives and antibacterials; Azides (organic); Catalysis; Chemical synthesis; Chemistry; Chemistry and Materials Science; E coli; Inorganic Chemistry; Physical Chemistry; Serum albumin; Water mediated; 1,4-Dihydropyridine; Hybrids; Anti-bacterial; 1,2,3-Triazole; Anti-inflammatory
• ISSN: 0922-6168; 1568-5675
• DOI: 10.1007/s11164-016-2614-8

Design and synthesis of a new series of 1,2,3-triazolyl-1,4-dihydropyridine hybrids (
5a
–
5l
) have been accomplished by a one-pot multicomponent reaction of
o
-propargyl salicylaldehyde/
o
-propargyl naphthaldehyde, β-keto compounds, ammonium acetate, and organic azides in short reaction times. In vitro antibacterial studies of the newly synthesized hybrids were investigated against four different human pathogens, viz.
S. aureus
,
Proteus mirabilis
,
E. Coli
, and
K. Pnemonia
, and the results were compared with that of the standard drug, tetracycline. Also, their anti-inflammatory activity was studied against bovine serum albumin (BSA) and compared with that of the reference drug, dichlofenac. Some of the hybrids show good antibacterial and anti-inflammatory activities comparable with that of the reference drugs.
Graphical Abstract