Synthesis and properties of quinazoline derivatives containing cymantrenyl group

• Published in: Russian chemical bulletin Vol. 66; no. 2; pp. 327 - 335
• Main Authors: Kelbysheva, E. S., Telegina, L. N., Ershova, E. A., Strelkova, T. V., Ezernitskaya, M. G., Nosova, E. V., Smol´yakov, A. F., Dolgushin, F. M., Loim, N. M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-02-2017; Springer Nature B.V
• Subjects: Aldehydes; Alkylation; Bromides; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Condensation; Derivatives; Fluorescence; Fragmentation; Full Articles; Inorganic Chemistry; Organic Chemistry; Potassium; Sodium; Synthesis; cymantrene; organomanganese compounds; fluorescence; condensation; alkylation; X-ray analysis; quinazolines
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-017-1735-6

The synthesis of new quinazoline derivatives with 2,3- and 4-positioned cymantrenyl fragment is described. Alkylation of 2-substituted quinazolin-4-ones with cymantrenylalkyl bromides on using K
2
CO
3
, potassium
tert
-butoxide, and sodium hydride as bases has been studied. It is established for the first time that condensation of 2-methylquinazolin-4-ones with aldehydes can cause elimination of the substituent at the nitrogen atom in position 3. The new cymantrene derivatives possess fluorescence properties.