Synthesis and Antimicrobial Activity of 5-(Het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones

A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized comp...

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Bibliographic Details
Published in:	Russian journal of general chemistry Vol. 90; no. 7; pp. 1222 - 1228
Main Authors:	Gein, V. L., Rubtsova, D. D., Bobyleva, A. A., Ryabova, O. V., Novikova, V. V., Kasimova, N. N., Yankin, A. N.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-07-2020 Springer Nature B.V
Subjects:	Aldehydes Aromatic compounds Carbonyls Chemistry Chemistry and Materials Science Chemistry/Food Science Fungicides Synthesis antibacterial activity 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones antifungal activity
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Summary:	A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.
ISSN:	1070-3632 1608-3350
DOI:	10.1134/S1070363220070087