Composition and properties of the reaction products of p-cresol with camphene

• Published in: Russian chemical bulletin Vol. 68; no. 5; pp. 993 - 999
• Main Authors: Chukicheva, I. Yu, Buravlev, E. V., Dvornikova, I. A., Fedorova, I. V., Chernysheva, G. A., Aliev, O. I., Smol’yakova, V. I., Anishchenko, A. M., Sidekhmenova, A. V., Plotnikov, M. B., Kutchin, A. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-05-2019; Springer Nature B.V
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Endothelium; Erythrocytes; Full Article; Inorganic Chemistry; Organic Chemistry; Pharmacology; Reaction products; Toxicity; erythrocyte deformability; erythrocyte osmotic resistance; erythrocyte aggregation; 2,6-diisobornyl-4-methylphenol; endothelial dysfunction; hemorheological activity; platelet aggregation
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-019-2509-0

The products of the reaction between
p
-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.