Synthesis and vasorelaxant and antiplatelet activities of a new series of (4-Benzylphthalazin-1-ylamino)alcohol derivatives
A new series of phthalazine derivatives was synthesized by reaction of phthalic anhydride and different substituted phenylacetic acids to yield the benzyliden-3H-isobenzofuran-1-one intermediates 2a – d . Treatment of them with hydrazine afforded 4-benzyl-2H-phthalazin-1-one derivatives 3a – d , whi...
Saved in:
Published in: | Medicinal chemistry research Vol. 26; no. 8; pp. 1682 - 1688 |
---|---|
Main Authors: | , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
New York
Springer US
01-08-2017
Springer Nature B.V |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | A new series of phthalazine derivatives was synthesized by reaction of phthalic anhydride and different substituted phenylacetic acids to yield the benzyliden-3H-isobenzofuran-1-one intermediates
2a
–
d
. Treatment of them with hydrazine afforded 4-benzyl-2H-phthalazin-1-one derivatives
3a
–
d
, which were substituted with the corresponding aminoalkylalcohol to obtain the (4-benzylphthalazin-1-ylamino)alcohol derivatives
4a
–
h
. In general, these phthalazine derivatives relaxed the contractions produced by phenylephrine both in intact or endothelium-denuded aortic rings. In addition, platelet aggregation induced by thrombin was also inhibited by compounds
4c
and
4g
. |
---|---|
ISSN: | 1054-2523 1554-8120 |
DOI: | 10.1007/s00044-017-1879-9 |