Protective effects of three luteolin derivatives on aflatoxin B1-induced genotoxicity on human blood cells

• Published in: Medicinal chemistry research Vol. 25; no. 11; pp. 2567 - 2577
• Main Authors: Orhan, Furkan, Çeker, Selçuk, Anar, Mustafa, Agar, Guleray, Arasoglu, Tulin, Gulluce, Medine
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-11-2016; Springer Nature B.V
• Subjects: Aflatoxin B1; Aflatoxins; Antioxidants; Biochemistry; Biomedical and Life Sciences; Biomedicine; Blood cells; Blood plasma; Cell Biology; Genotoxicity; Glucosides; Lymphocytes; Original Research; Pharmacology/Toxicology; Antioxidants; Luteolin derivatives; Anti-genotoxic potential; Micronucleus
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-016-1681-0

In the present study, we aimed to investigate the genotoxic and anti-genotoxic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using human cells. In the micronucleus test, the human lymphocytes were exposed to aflatoxin B
1
, the luteolin derivatives and a mixture of the two for 72 h. Furthermore, we have evaluated the levels of antioxidants of human whole blood plasma in order to clarify the possible mechanisms that may contribute to the anti-genotoxic activity of the luteolin derivatives. According to the results obtained from the micronucleus test, the highest protection rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against aflatoxin B1 were 32.09, 35.55 and 37.50 %, respectively. Similarly, these three luteolin derivatives ameliorated the level of antioxidants altered from aflatoxin B
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.