One-Pot Synthesis of 3-Oxocycloalka[c]pyridines

One-Pot Synthesis of 3-Oxocycloalka[c]pyridines

A new efficient one-pot procedure has been developed for the synthesis of 1-substituted partially hydrogenated 3-oxocycloalka[ c ]pyridine-4-carbonitriles by reaction of cyclopentanone or cyclohexanone with morpholine, acyl chloride, and cyanoacetamide. The proposed procedure is advantageous due to...

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Bibliographic Details
Published in:Russian journal of organic chemistry Vol. 57; no. 10; pp. 1748 - 1752
Main Authors: Sirakanyan, S. N., Geronikaki, A., Kartsev, V. G., Hakobyan, E. K., Hovakimyan, A. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-10-2021
Springer Nature B.V
Subjects:
Acetyl chloride
Chemistry
Chemistry and Materials Science
Cyclohexanone
Morpholine
Organic Chemistry
Pyridines
Reaction time
3-oxocycloalka
diketone
pyridines
one-pot synthesis
cyclization
enamine
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Summary:A new efficient one-pot procedure has been developed for the synthesis of 1-substituted partially hydrogenated 3-oxocycloalka[ c ]pyridine-4-carbonitriles by reaction of cyclopentanone or cyclohexanone with morpholine, acyl chloride, and cyanoacetamide. The proposed procedure is advantageous due to shorter reaction time and smaller amounts of the solvents and reactants.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021100250