Mechanical and thermal studies of metronidazole crystals

• Published in: Indian journal of physics Vol. 87; no. 10; pp. 1001 - 1004
• Main Authors: Ramukutty, S., Jeyasudha, R., Ramachandran, E.
• Format: Journal Article
• Language: English
• Published: India Springer India 01-10-2013; Springer Nature B.V
• Subjects: Astrophysics and Astroparticles; Diffraction; Hardness testing; Original Paper; Physics; Physics and Astronomy; Single crystals; Thermodynamics; Thermogravimetric analysis; 62.20.Qp; Thermogravimetric analysis; 42.70.Jk; Metronidazole; XRD; Hardness; 61.05.cp
• ISSN: 0973-1458; 0974-9845
• DOI: 10.1007/s12648-013-0337-x

Single crystals of metronidazole have been synthesized natural evaporation method. The grown crystal has been confirmed using single crystal X-ray diffraction analysis. Mechanical behavior has been determined using Vickers hardness measurement. Work-hardening coefficient and Newtonian resistance pressure of the crystal have been estimated. Kinetic analysis of the thermogravimetric data has been carried out by using Coats-Redfern relation. Activation energy, frequency factor and order of reaction have been also calculated. The Arrhenius equation for metronidazole is k = 0.38 × 108 e
−76.679/
RT
mol
−1
s
−1
. Thermodynamic parameters have been also determined.